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#21
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06-12-2011, 12:43 AM
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 My Rank: LANCE CORPORAL Poster Rank:2512 Male Join Date: Mar 2011 Posts: 172
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Re: Severe Case of Stevens Johnson Syndrome/Toxic Epidermal Necrolysis
Wasn't meaning to be evasive. In this case it was Children's Motrin. I have not seen a compiled list of all drugs that may potentially cause this but here are some: sulfonamides (bactrim) and other antibiotics, piroxicam, meloxicam, and other NSAIDs (Motrin [ibuprophen] included), allopurinol, and anticonvulsants (carbamazepine, phenytoin, lamotrigine, valproic acid, etc). For the anticonvulsants it has been found that East Asians may be at highest risk for Carbamazepine or Phenytoin-induced SJS if they have mutations in HLA-B*1502. Most clinicians screen this population prior to initiating those drugs. Tylenol (in normal therapeutic doses) has NOT been shown to have this as a potential side effect and is one of the safest drugs. This is such a rare condition that the medical community is still trying to find a way to detect individuals who may be at increased risk. We know about HLA-B*1502 for East Asians but pretty much everyone else is a question mark. Of those drugs that have been linked to SJS/TEN, typically this immune response will be experienced within the first month of therapy if it will occur at all. Warnings on all the above prescription drugs appear in the patient leaflets distributed with their medications. However over-the-counter medications are not as strictly regulated and warnings unfortunately are more sparse. When in doubt ask your druggist about risks and benefits of the medications you are going to ingest. All that being said the incidence of these conditions is extremely rare (<6.1 cases per million people per year) |
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#24
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06-13-2011, 02:40 PM
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 So Fucking Banned Poster Rank:261 Join Date: May 2010 Posts: 5,346 Mentioned: 4 Post(s) Quoted: 41 Post(s)
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Re: Severe Case of Stevens Johnson Syndrome/Toxic Epidermal Necrolysis
Thank you Mirror,for the added info.!!! I really hope this might help parent's out there a little!!  |
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#25
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06-13-2011, 03:57 PM
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| My Rank: LANCE CORPORAL Poster Rank:2512 Male Join Date: Mar 2011 Posts: 172
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Re: Severe Case of Stevens Johnson Syndrome/Toxic Epidermal Necrolysis
No problem Softballmama. I really hope we get a handle on SJS and TEN and stop them from occurring altogether!
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#27
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06-13-2011, 07:37 PM
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 My Rank: PRIVATE Poster Rank:14124 Male Join Date: Jan 2009 Posts: 6 Mentioned: 0 Post(s) Quoted: 0 Post(s)
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Re: Severe Case of Stevens Johnson Syndrome/Toxic Epidermal Necrolysis
This story is absolutely heart-breaking...Poor girl, so young and so innocent. No one deserves this type of death, let alone a child. Mirrormere, you seem like a stand-up individual, thank you for the information. People like you are half of the reason I love this website so much  |
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#29
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06-14-2011, 01:04 AM
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| My Rank: LANCE CORPORAL Poster Rank:2512 Male Join Date: Mar 2011 Posts: 172
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Re: Severe Case of Stevens Johnson Syndrome/Toxic Epidermal Necrolysis
If it's treated early and does not become TEN then SJS itself is not typically life threatening. Once it moves into TEN and the skin (largest organ in the body) starts dying and sloughing off its outer layers, the risk of fatal infection and dehydration increases dramatically. The mortality rate is 5% for SJS involving less than 10% of body surface area. With TEN you are talking about a mortality rate of 30-40%. |
