Swelling of the Lips.

SavageGlow · #1 ● 01-26-2023, 02:06 AM

A 24-year-old man presented with a 1-year history of increasing swelling in the upper lip with a painful ulcer on the external oral mucosa. On physical examination, the upper lip showed swelling cheilitis, crusting and fissuring lesions. On the external fold of the upper lip, there were ulcerative lesions with necrotic and oedematous labial mucosa (figure 1A,B). The patient did not show any other clinical or biological abnormalities. Upper lip biopsy revealed organised non-caseating granulomas containing epithelioid cells and multinucleated giant cells surrounded by nodular inflammatory infiltrate composed of lymphocytes and plasma cells. A diagnosis of orofacial granulomatosis was made. Tuberculosis, sarcoidosis, Crohn's disease and lymphoma were eliminated as possible causes. Melkersson-Rosenthal syndrome and foreign body giant cell granuloma were also ruled out. Further microbiological investigations were carried out in order to locate the granulomatosis-causing agents. The serology for Leishmania spp was positive. PCR of an upper lip fragment confirmed the diagnosis of leishmaniasis. The patient was treated with intramuscular Glucantime for 20 days. The lesions steadily improved with total recovery (figure 2).