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#1
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04-03-2012, 03:58 PM
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Picture of a Small Harlequin Baby
The fact that this infant is noted to be 8 months old in this photograph is indicative of a form of ichthyosis other than Harlequin-type. Prior to the 1950s, there were only a small handful of cases with that syndrome that survived beyond half a year, and prior to the invention of Isoretinoin (Isotrex/Accutane) in the early 1980s, there were no cases that survived beyond their late-childhood years. At birth and in infancy, severe lamellar ichthyosis has the potential to appear very similar to Harlequin-type ichthyosis, but with thinner “scales” and cracked tiles of skin. They’re also both autosomal recessive genetic disorders. Despite their similar presentations, the various forms of lamellar ichthyosis are due to genes which cause proliferative hyperkeratosis (creating and shedding keratin at a much higher rate than normal), and Harlequin-type ichthyosis is due to a combination of proliferative and retentive hyperkeratosis - that is, they both create keratinized skin layers much too fast, but they don’t shed them as fast as they’re created. |
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#4
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05-03-2012, 12:41 AM
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Re: Picture of a Small Harlequin Baby
I remember a death vid VHS had video of one of these babies, it's parents were displaying it for donations, gave alot of my friends nightmares and even a few girls I knew got scared to ever have babies
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#10
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05-24-2012, 08:17 PM
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Re: Picture of a Small Harlequin Baby
The new post of the older photo must be a milder case than the rest of them. He/she also looks better in black and white. She appears to be able to see, too. I know of a few older people who survived and can also see. They're on here somewhere.
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