[Xploit Machine]

The Walking Dead ..

[mr_feelgood]

That dope must be pretty strong. Id try it

[Major_Tom]

Originally Posted by mr_feelgood ↗

That dope must be pretty strong. Id try it

Meet me in the alley behind the bar in 5.

[HIGHTECHDUDE]

[DarkSighted]

Many years ago I was walking along a sidewalk at the edge of a park, and I saw a mouse doing just about that: it was up on its hind legs (haunches) but curled sharply forward at about between-shoulder-blades, front legs together over its nose, standing up dead. Phuqqin' weird.

[rohmell]

Wow, I didn't know there was more to the X-Files theme song.

[kellyhound]

Kensington neighbourhood, in Philly.


Xylazine, also known as “tranq,” is a veterinary tranquilizer that has been found in some illicit drug supplies and synthetic opioids like illicitly manufactured fentanyl can turn you into zombies.(Tranq-dope). Bet they won't live long. They take fentanyl (sometimes unwanted or knowing) with tranq added to lengthen fentanyl’s euphoric effects.

Opioid misuse and addiction represent an ongoing public health crisis. In the United States, the annual number of deaths attributed to opioids now exceeds the annual number of deaths from firearms and motor vehicle accidents (Center for Disease Control, 2023b). Because nonlethal overdoses are much more common than lethal overdoses, annual mortality rates significantly underestimate the proportion of the population who experience clinically significant but nonlethal consequences of an acute overdose (Center for Disease Control, 2023a). Complicating matters further, ~80% of opioid overdoses in the United States are characterized by polysubstance use involving a nonopioid drug (Jones et al., 2018). Many of these drugs increase the lethal effects of opioids, making lethal overdoses more common and less sensitive to reversal by traditional rescue medications.

The fully synthetic mu opioid receptor agonist, fentanyl, has driven the most recent wave of the opioid overdose epidemic, partly because of its increased availability and greater potency relative to heroin (Gladden, 2016; O’Donnell, 2017). Between 2019 and 2022, the monthly percentage of fentanyl-related overdose deaths increased across 21 jurisdictions in the United States by over 200% (Kariisa et al., 2023). Concomitant with this increase in fentanyl-related mortality, seizures of xylazine-adulterated fentanyl (“tranq-dope”) increased by a similar amount across many of these jurisdictions (United States Drug Enforcement Agency, 2023). Xylazine is an alpha-2 adrenergic receptor agonist used as a general anesthetic in veterinary medicine but not approved for use in humans. Both the Center for Disease Control and the US Drug Enforcement Administration have identified fentanyl-xylazine combinations as a significant public health threat (Center for Disease Control, 2023c; United States Drug Enforcement Agency, 2023), and reports of the human impact of this deadly drug combination has been described in both scientific (Gipson and Strickland, 2023) and lay (Hoffman, 2023) publications. The rapid increases in lethal drug overdoses attributed to this drug combination recently prompted the White House Office of National Drug Control Policy to declare xylazine combined with fentanyl an emerging threat to the United States (Office of National Drug Control Policy, 2023). Although evidence suggesting xylazine increases fentanyl-related morbidity and mortality is rapidly growing, no studies have quantified the interactions between these drugs on lethality.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10557575/

[mr_feelgood]

Thank God for methadone
Only thing that stopped my stupid ass from that mess.

[zeb247]

Looks like Kensington Ave in Philly.

[Nates8er]

Good god I’d really love to have some