[reubthadude]

Man that meth does some thangs to you...terrible how physically destructive it is.

[Agapeti]

All it takes is the first time to go from one pic to the other. Sadly not even this is a deterrent for some people. Don't use that first time and this will not happen.

[Draculina]

Those skin lesions look sooo painful! Some of those girls were so pretty...you'd think theyd stay away from meth from vanity alone.

[Shakey]

Must be some good shit.

[Morbid75]

Originally Posted by LadyCPlum ↗

Does prolonged meth use cause some form of severe acne? It's odd but it almost seems as if you could reverse the "before and after" shots and it would be like a Proactiv commercial

Meth shuts down the kidneys among other things and also causes another condition called formication where it feels like bugs crawling under the skin. Users pick and scratch at their skin which causes sores that do not heal because the kidneys are shutting down. Meth is rough but krokodili is worse.

[eeeuuuwww]

Just say NO.
Many were quite attractive.
I knew a crack addict who's before and after photos would fit right in here. Lovely, intelligent woman (a few years ago. I guess the decline over a year or so is less jarring than seeing side by side photos like that). I assume no one who tries it thinks they'll get hooked. Sad.

[DiamondSmiles]

Originally Posted by LadyCPlum ↗

Does prolonged meth use cause some form of severe acne? It's odd but it almost seems as if you could reverse the "before and after" shots and it would be like a Proactiv commercial

It appears to, but, my youngest brother was always picking at his skin.

He thought things were crawling inside him. More his legs and arms than face though.

Did you see the video of the woman on meth hosing herself down on here?

I think it fucks with your nerves.

[DiamondSmiles]

Originally Posted by morbid75 ↗

Meth shuts down the kidneys among other things and also causes another condition called formication where it feels like bugs crawling under the skin. Users pick and scratch at their skin which causes sores that do not heal because the kidneys are shutting down. Meth is rough but krokodili is worse.

I didn't see that you already answered this, morbid.

Krokodil is a death sentence.

People can live long lives on meth. Look at Lemmy Kilmister!

Sorry about that

[Nick_ufc]

fugly sluts

[ro4eva]

Originally Posted by morbid75 ↗

Meth shuts down the kidneys among other things and also causes another condition called formication where it feels like bugs crawling under the skin. Users pick and scratch at their skin which causes sores that do not heal because the kidneys are shutting down. Meth is rough but krokodili is worse.

I don't mean to insult your intelligence, but I wonder where you studied psychotropic pharmacology, because methamphetamine use (acute or chronic) does not cause otherwise healthy and functioning kidneys to suddenly begin to shut down and ultimately fail.

Methamphetamine use is no more dangerous to a user's kidneys than excessive consumption of alcoholic beverages (drinking to get drunk).

Methamphetamine use is however very dangerous to a chronic user's brain, as it has been shown to cause extensive and irreversible damage to dopamine and serotonin neurons (known as neurotoxicity) - especially with long term use.

Typically, former long term meth users will severely struggle to enjoy their lives without the reward, pleasure, and satisfaction centers (dopamine and serotonin) of their brains malfunctioning.

Notice how when you drink booze, you need to piss more frequently? That's because ethyl alcohol causes a decrease in secretion of the hormone known as vasopressin from the pituitary gland.

This fools the brain into thinking that the body has retained too much water, so it signals the kidneys to get of what it sees as excess water so that the body's critical electrolyte balance remains stable.

What's really happening however is that the kidneys are filling up the bladder for excretion with water which the body actually needs.

This is why after a night of heavy drinking, chances are you will wake up with a hangover - because your body is dehydrated.

One effective method of minimizing the chances of a hangover after a night of heavy drinking is to alternate every alcoholic beverage with a bottle of dwater.

Anyways, assuming he's not mixing it with another drug, the main pathway for a methamphetamine user to fatally fuck up his kidneys is as follows:

--> User consumes a recreational (usually high) dose...
--> Meth binds to norepinephrine receptors (among other things) and causes a massive, cascading release of the potent neurotransmitter into NA* synapses throughout the body.
--> Norepinephrine is used by the body to regulate vital functions, such as heart rate and blood pressure.
--> The increase in heart rate due to severely increased levels of norepinephrine in NA* synapses throughout the body causes a significant increase in body temperature.
--> Meth user's unusually high body temperature trips a negative feedback alarm in his brain and nervous system.
--> Our meth user begins to sweat profusely. This is triggered by the autonomic nervous system in an effort to use the cooling droplets of water and ensuing evaporation thereafter to cool his feverishly-feeling body.
--> Meth user is too high, too horny, and probably having unprotected sex to remember to drink some fluids which will not only rehydrate him, but also will help keep sodium levels in his body in the green, such as Gatorade (water won't cut it because it has next to zero amount of sodium in it, especially if it's distilled water).
--> As the user's heart rate continues to increase, so too will his blood vessels constrict. This causes a reduced circulation of much-needed oxygenated blood throughout the body.
--> Without that much-needed oxygen-rich blood, meth head's kidneys cannot function properly.
--> With the sharp increase in body temperature, and a lack of circulating oxygen, muscle tissue starts to break down. As an example, if the heart does not receive oxygen-rich blood from the lungs, its muscle tissue will start to break down... right after the very painful heart attack.
--> As meth head's muscles break down, they produce proteins that are absorbed by the kidneys, which mixes them with the day's batch of fresh urine and sends this brown-looking, particularly smelly piss to the bladder.
--> However, because they are starved of oxygen, the kidneys cannot even keep themselves in working order (much less make more pee).
--> Meth head's kidneys begin to shut down, and he eventually goes into acute renal failure.
--> At this point, meth head is probably throwing up, feeling really confused, very weak, and about to collapse into a coma, which he only has a chance of waking up from if he's rushed to the ER, and the medical team knows he used some meth.

*NA is short for "noradrenaline," which is another name for "norepinephrine."