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#1
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01-09-2023, 09:44 PM
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 These are the rooms Poster Rank:25 of ruin. Join Date: Sep 2014 Posts: 54,011 Mentioned: 145 Post(s) Quoted: 30403 Post(s)
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Acne Treatment Gone Wrong.
A healthy 17-year-old girl with inflammatory acne had failed to respond to topical tretinoin, benzoyl peroxide, and oral minocycline. She was subsequently treated with oral isotretinoin at 0.5 mg/kg/d. Two days later, she developed fever, arthralgias, and progressive severe inflammatory lesions on the back, chest, shoulders, and sides of her face, many of which were ulcerated (Figures 1-3). The isotretinoin was discontinued, and she was started on oral prednisone at 1 mg/kg/d which was tapered over 4 months. She had a recurrence a week later and required 0.5 mg/kg/d of oral steroids which were tapered over the subsequent 2 months. She was also treated concurrently with oral doxycycline, which was continued for several months after the steroids were discontinued.
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#2
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01-09-2023, 11:45 PM
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 ★ Legacy Member ★ Poster Rank:247 So many choices now Join Date: Jul 2015 Posts: 5,548 Mentioned: 15 Post(s) Quoted: 2120 Post(s)
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Re: Acne Treatment Gone Wrong.
Holy snappin' arseholes Martha! One of my daughters goes into severe meltdown when she has one period zit. I'll have to show her this and give her the "Someone always has it worse than you" speech. |
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#3
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01-09-2023, 11:51 PM
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| These are the rooms Poster Rank:25 of ruin. Join Date: Sep 2014 Posts: 54,011 Mentioned: 145 Post(s) Quoted: 30403 Post(s)
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Re: Acne Treatment Gone Wrong.
Mine has a whole regimen of expensive face washes and lotions. Zits are serious.  |
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#4
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01-09-2023, 11:54 PM
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| ★ Legacy Member ★ Poster Rank:247 So many choices now Join Date: Jul 2015 Posts: 5,548 Mentioned: 15 Post(s) Quoted: 2120 Post(s)
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Re: Acne Treatment Gone Wrong.
I'm in my mid-sixties and I've like three pimples in my entire life. I just can't relate.
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#9
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01-10-2023, 04:05 AM
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 ✝Mudderator from Hell✝ Poster Rank:10 e-mail Join Date: Oct 2006 Posts: 94,976
Contributions: 817
Mentioned: 472 Post(s) Quoted: 10078 Post(s)
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Re: Acne Treatment Gone Wrong.
Acne fulminans is a rare skin disorder, and hence its etiology is not well understood. Acne fulminans may be triggered by the use of high doses of isotretinoin when initiating treatment in patients with severe acne. Also, elevated levels of testosterone may have a role in the pathogenesis. Anabolic steroids are known to increase levels of sebum and density of Propionibacterium acnes. Bodybuilders who use anabolic steroids develop acne fulminans within a very short time. The belief is that the density of P. acnes or related antigens triggers the immune system and leads to acne fulminans. Others believe the condition to be autoimmune-mediated because circulating immune complexes have appeared in some patients with acne fulminans. |
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#10
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01-10-2023, 12:01 PM
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 Addict Of Misery Poster Rank:69 Join Date: May 2012 Posts: 22,176 Mentioned: 18 Post(s) Quoted: 9547 Post(s)
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Re: Acne Treatment Gone Wrong.
Acne doesn't seem so bad now, eh?
__________________ A deep well of despair I found, the day my dreams came true... |
