Go Back  

Scientists Have Discovered How Herpes Works 

Current Rating:

Join NowJoin Now
Old 07-28-2013, 06:16 PM
GODREKR's Avatar
✖ The Antique Christ ✖
Poster Rank:92
Sin Eater
Join Date: Jan 2009
Contributions: 28
Mentioned: 8 Post(s)
Quoted: 88 Post(s)
Activity Longevity
0/20 16/20
Today Posts
0/11 ssss11449
Scientists Have Discovered How Herpes Works

Herpes Virus Blasts DNA into Human Cells, Says New Study

Herpes simplex virus 1 has an internal pressure eight times higher than a car tire, and uses it to literally blast its DNA into human cells, according to a new study published online in the Journal of the American Chemical Society.

The study provides the first experimental evidence of high internal pressure within a virus that infects humans – a phenomenon previously only attributed to viruses that infect bacteria.

“Despite billions of years of evolution separating eukaryotic viruses and bacteriophages, the existence of an internal pressure capable of powering the ejection of DNA into a host cell has been conserved. This suggests that it is a key mechanism for viral infection across organisms and presents us with a new drug target for antiviral therapies,” said Dr Alex Evilevitch of Carnegie Mellon University, senior author of the study published in the Journal of the American Chemical Society.

Many viruses, whether they infect bacteria, plants or animals, are adept at packing long stretches of DNA or RNA within their nanometer-sized protein shells.

Herpes simplex virus 1 (HSV-1) contains double-stranded DNA that is 400 times longer than the radius of the viral shell it fills.

The DNA gets packaged so tightly that it bends upon itself, resulting in repulsive forces that exert tremendous energy and pressure on the virus’s outer shell. When HSV-1 infects a cell, it enters through the outer cell membrane and makes its way to the cell nucleus, where it docks in a small hole found in the nuclear membrane. That act is like a key opening a lock that allows the HSV-1 to eject its DNA into the cell nucleus.

For years, scientists hypothesized that a high internal pressure inside eukaryotic viruses like HSV-1 enabled the virus to shoot its DNA into the host cell’s nucleus. But it was impossible to measure HSV-1′s internal pressure without knowing how to release the viral DNA in a controlled, experimental setting.

Dr Evilevitch’s colleagues Prof William Newcomb and Prof Jay Brown from the University of Virginia’s School of Medicine discovered protein called UL6 that, when degraded, caused DNA to exit the virus.

In their experiments, they degraded UL6, which triggered HSV-1 to eject its DNA. At the same time, they applied an external force to the virus and monitored how much DNA was released. When the external pressure reached tens of atmospheres, HSV-1 didn’t release any DNA, indicating that the internal and external pressure were equal.

“This measurement of high internal pressure – tens of atmospheres – within a human virus is a fundamentally important discovery of the physical-chemical mechanism of eukaryotic viral infection,” Dr Evilevitch said.

“The mechanism of pressurized infection found in HSV-1 is applicable to any of the eight known Herpes viruses that cause disease in humans, including Varicella zoster virus, which causes chickenpox in children and shingles in adults, and the Epstein-Barr virus, which causes mononucleosis and is associated with several types of cancer, such as Hodgkin’s lymphoma.”

Below: Dr Alex Evilevitch and his colleagues provide the first experimental evidence of a high internal pressure of tens of atmospheres within Herpes simplex virus 1, resulting from the confined genome. NPC – nuclear pore complex (Bauer DW et al)

Your Source For Death Pictures and Death Video

Reply With Quote
The Following User Says Thank You to GODREKR For This Useful Post:
Old 07-28-2013, 06:22 PM
ices's Avatar
Poster Rank:238
Join Date: Mar 2010
Mentioned: 11 Post(s)
Quoted: 641 Post(s)
Activity Longevity
3/20 14/20
Today Posts
0/11 sssss3620
Re: Scientists Have Discovered How Herpes Works

Hmmm, I forsee lots and lots of money for a cure of Herpes.

Seeing how much of a social stigma is attached to herpes, I would hope they keep the cost manageable.

Reply With Quote
The Following 2 Users Say Thank You to ices For This Useful Post:
HairyGrape, kellyhound
Old 07-29-2013, 02:55 PM
kellyhound's Avatar
✝Moderator from Hell✝
Poster Rank:9
Join Date: Oct 2006
Contributions: 398
Mentioned: 81 Post(s)
Quoted: 1728 Post(s)
Activity Longevity
16/20 20/20
Today Posts
7/11 ssss60913
Re: Scientists Have Discovered How Herpes Works

hopefully a step closer for a real cure.

Reply With Quote
Old 07-29-2013, 07:25 PM
Angelahh's Avatar
★ Server Supporter ★
Poster Rank:83
Join Date: Nov 2011
Contributions: 41
Mentioned: 11 Post(s)
Quoted: 438 Post(s)
Activity Longevity
0/20 10/20
Today Posts
0/11 ssss12278
Re: Scientists Have Discovered How Herpes Works

Title made me laugh at first... like it takes a scientist to know you shouldnt be a dirty whore and sleep with dirty dicks

Reply With Quote
The Following 2 Users Say Thank You to Angelahh For This Useful Post:
fenek, rob666
The Following Users Disliked This Post By Angelahh:
Old 08-01-2013, 02:40 PM
GregK's Avatar
Poster Rank:313
Join Date: Sep 2012
Mentioned: 5 Post(s)
Quoted: 461 Post(s)
Activity Longevity
0/20 9/20
Today Posts
0/11 sssss2474
Re: Scientists Have Discovered How Herpes Works

Wow. Thats pretty damn interesting.

Reply With Quote
Old 08-01-2013, 03:16 PM
knuggy's Avatar
Poster Rank:424
Join Date: Feb 2011
Contributions: 1
Mentioned: 1 Post(s)
Quoted: 32 Post(s)
Activity Longevity
3/20 12/20
Today Posts
0/11 sssss1618
Re: Scientists Have Discovered How Herpes Works


Reply With Quote
Old 08-01-2013, 09:18 PM
petedeamon's Avatar
Poster Rank:375
Join Date: Sep 2009
Mentioned: 0 Post(s)
Quoted: 86 Post(s)
Activity Longevity
0/20 14/20
Today Posts
0/11 sssss1920
Re: Scientists Have Discovered How Herpes Works

Death cures everything

Reply With Quote
The Following User Says Thank You to petedeamon For This Useful Post:
Gaydolf Shitler
Old 08-01-2013, 09:59 PM
rob666's Avatar
So Fucking Banned
Poster Rank:54
Join Date: May 2009
Mentioned: 59 Post(s)
Quoted: 8621 Post(s)
Activity Longevity
0/20 15/20
Today Posts
0/11 ssss16569
Re: Scientists Have Discovered How Herpes Works

I already knew how it worked, you get drunk don't wrap it up and wind up with blisters on your dick

Reply With Quote
The Following User Says Thank You to rob666 For This Useful Post:

Powered by vBulletin Copyright 2000-2010 Jelsoft Enterprises Limited.

Search Engine Friendly URLs by vBSEO