Go Back  

Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities 

Current Rating:

Join NowJoin Now
 
  #1  
Old 07-30-2013, 02:55 PM
GODREKR's Avatar
GODREKR
Offline:
✖ The Antique Christ ✖
Poster Rank:92
Sin Eater
Join Date: Jan 2009
Contributions: 28
 
Mentioned: 8 Post(s)
Quoted: 90 Post(s)
Activity Longevity
0/20 16/20
Today Posts
0/11 ssss11449
Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities

Quote:
Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities, Mouse Study Suggests

July 24, 2013 — Regular marijuana use in adolescence, but not adulthood, may permanently impair brain function and cognition, and may increase the risk of developing serious psychiatric disorders such as schizophrenia, according to a recent study from the University of Maryland School of Medicine. Researchers hope that the study, published in Neuropsychopharmacology -- a publication of the journal Nature -- will help to shed light on the potential long-term effects of marijuana use, particularly as lawmakers in Maryland and elsewhere contemplate legalizing the drug.

"Over the past 20 years, there has been a major controversy about the long-term effects of marijuana, with some evidence that use in adolescence could be damaging," says the study's senior author Asaf Keller, Ph.D., Professor of Anatomy and Neurobiology at the University of Maryland School of Medicine. "Previous research has shown that children who started using marijuana before the age of 16 are at greater risk of permanent cognitive deficits, and have a significantly higher incidence of psychiatric disorders such as schizophrenia. There likely is a genetic susceptibility, and then you add marijuana during adolescence and it becomes the trigger."

"Adolescence is the critical period during which marijuana use can be damaging," says the study's lead author, Sylvina Mullins Raver, a Ph.D. candidate in the Program in Neuroscience in the Department of Anatomy and Neurobiology at the University of Maryland School of Medicine. "We wanted to identify the biological underpinnings and determine whether there is a real, permanent health risk to marijuana use."

The scientists -- including co-author Sarah Paige Haughwout, a research technician in Dr. Keller's laboratory -- began by examining cortical oscillations in mice. Cortical oscillations are patterns of the activity of neurons in the brain and are believed to underlie the brain's various functions. These oscillations are very abnormal in schizophrenia and in other psychiatric disorders. The scientists exposed young mice to very low doses of the active ingredient in marijuana for 20 days, and then allowed them to return to their siblings and develop normally.

"In the adult mice exposed to marijuana ingredients in adolescence, we found that cortical oscillations were grossly altered, and they exhibited impaired cognitive abilities," says Ms. Raver. "We also found impaired cognitive behavioral performance in those mice. The striking finding is that, even though the mice were exposed to very low drug doses, and only for a brief period during adolescence, their brain abnormalities persisted into adulthood."

The scientists repeated the experiment, this time administering marijuana ingredients to adult mice that had never been exposed to the drug before. Their cortical oscillations and ability to perform cognitive behavioral tasks remained normal, indicating that it was only drug exposure during the critical period of adolescence that impaired cognition through this mechanism. The researchers took the next step in their studies, trying to pinpoint the mechanisms underlying these changes and the time period in which they occur.

"We looked at the different regions of the brain," says Dr. Keller. "The back of the brain develops first, and the frontal parts of the brain develop during adolescence. We found that the frontal cortex is much more affected by the drugs during adolescence. This is the area of the brain controls executive functions such as planning and impulse control. It is also the area most affected in schizophrenia."

Dr. Keller's team believes that the results have indications for humans as well. They will continue to study the underlying mechanisms that cause these changes in cortical oscillations. "The purpose of studying these mechanisms is to see whether we can reverse these effects," says Dr. Keller. "We are hoping we will learn more about schizophrenia and other psychiatric disorders, which are complicated conditions. These cognitive symptoms are not affected by medication, but they might be affected by controlling these cortical oscillations."

"This study is an example of how the basic science research taking place in our state-of-the-art laboratories can impact human health and inform health policy," says E. Albert Reece, M.D., Ph.D., M.B.A., Vice President for Medical Affairs at the University of Maryland and John Z. and Akiko K. Bowers Distinguished Professor and Dean of the University of Maryland School of Medicine. "We are proud of this groundbreaking discovery and look forward to watching this research develop further."
Source

Related Stories
How Marijuana Affects the Way the Brain Processes Emotional Information
Combined Chronic Alcohol and Marijuana Use During Youth Can Compromise White-Matter Integrity

Reply With Quote
The Following 6 Users Say Thank You to GODREKR For This Useful Post:
Dynamo47, JONESJIM, JustifiableHomicide, Kanda444, kellyhound, MisterX
  #2  
Old 07-30-2013, 04:09 PM
Eskimo Aids's Avatar
Eskimo Aids
Offline:
My Rank: LANCE CORPORAL
Poster Rank:2208
Join Date: May 2010
 
Mentioned: 0 Post(s)
Quoted: 8 Post(s)
Activity Longevity
0/20 13/20
Today Posts
0/11 ssssss128
Re: Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities

false

Reply With Quote
The Following User Says Thank You to Eskimo Aids For This Useful Post:
Stalker420
  #3  
Old 07-30-2013, 04:59 PM
Faline's Avatar
Faline
Offline:
♥ Moderator ♥
Poster Rank:2
Gore Goddess
Join Date: Jun 2009
Contributions: 226
 
Mentioned: 85 Post(s)
Quoted: 1894 Post(s)
Activity Longevity
0/20 15/20
Today Posts
0/11 ssss93392
Re: Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities

That's why my ex is so fucked up

Reply With Quote
The Following User Says Thank You to Faline For This Useful Post:
Viking64
  #4  
Old 07-30-2013, 05:00 PM
Lana-Banana's Avatar
Lana-Banana
Offline:
So Fucking Banned
Poster Rank:189
Artful Dodger
Join Date: Apr 2013
 
Mentioned: 32 Post(s)
Quoted: 3831 Post(s)
Activity Longevity
0/20 7/20
Today Posts
0/11 sssss5092
Re: Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities

TMoney

Reply With Quote
The Following Users Disliked This Post By Lana-Banana:
JustifiableHomicide
  #5  
Old 08-10-2013, 05:29 AM
THELORDABORTION's Avatar
THELORDABORTION
Offline:
My Rank: CORPORAL
Poster Rank:991
female
Join Date: Oct 2009
 
Mentioned: 1 Post(s)
Quoted: 20 Post(s)
Activity Longevity
0/20 14/20
Today Posts
0/11 ssssss436
Re: Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities

oh oh oh do one about methamphetamine! which btw is a million times worse...........no matter what your age

Reply With Quote
The Following User Says Thank You to THELORDABORTION For This Useful Post:
Stalker420
  #6  
Old 08-10-2013, 02:07 PM
candymosh's Avatar
candymosh
Offline:
My Rank: MAJOR
Poster Rank:124
Join Date: Dec 2009
 
Mentioned: 0 Post(s)
Quoted: 40 Post(s)
Activity Longevity
1/20 14/20
Today Posts
0/11 sssss8123
Re: Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities

interesting read but you have to wonder how much of it was funded by companies looking for those sorts of results.

Reply With Quote
The Following User Says Thank You to candymosh For This Useful Post:
spycosis
  #7  
Old 08-10-2013, 05:56 PM
Xfactor's Avatar
Xfactor
Offline:
Avoiding Limelight
Poster Rank:98
Male
Join Date: May 2009
Contributions: 5
 
Mentioned: 7 Post(s)
Quoted: 527 Post(s)
Activity Longevity
2/20 15/20
Today Posts
1/11 ssss10967
Re: Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities

Denial is another brain abnormality.

__________________
In this horrendous hath? Drowned in her hole.
Reply With Quote
The Following User Says Thank You to Xfactor For This Useful Post:
Lana-Banana
  #8  
Old 08-10-2013, 08:13 PM
ices's Avatar
ices
Offline:
My Rank: MASTER GUNNERY SERGEANT
Poster Rank:240
Male
Join Date: Mar 2010
 
Mentioned: 11 Post(s)
Quoted: 662 Post(s)
Activity Longevity
4/20 14/20
Today Posts
0/11 sssss3660
Re: Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities

You know there was a time when I was stupid enough to believe this horse shit, but not anymore.

Prescription drugs used to "calm" youngsters activities because the parents cannot cope are worse.

Bad diets as a means of shitty food and lack of exercise is worse.

Growing up in a bad neighbourhood is worse.

Being physically or mentally abused is worse.

So you're telling me that a natural plant, easily grown anywhere in the world is a fucking problem when it comes to mental health?

You have to be mentally ill to not see what living in the west can do to you. I believe the term is called western cancer.

Reply With Quote
The Following 5 Users Say Thank You to ices For This Useful Post:
dirty ike, Dynamo47, Feirefiz, fletch, JustifiableHomicide
  #9  
Old 08-10-2013, 09:02 PM
Kanda444's Avatar
Kanda444
Offline:
You holdin....?
Poster Rank:11
Join Date: May 2010
Contributions: 23
 
Mentioned: 228 Post(s)
Quoted: 20139 Post(s)
Activity Longevity
15/20 13/20
Today Posts
0/11 ssss49383
Re: Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities

i agree that this might be the case.

__________________
"High moral character is not a precondition for great moral accomplishments."
Reply With Quote
  #10  
Old 08-10-2013, 09:16 PM
Parannoyed's Avatar
Parannoyed
Offline:
My Rank: MASTER GUNNERY SERGEANT
Poster Rank:239
Male ლ(ಠ益ಠლ)
Join Date: Dec 2010
 
Mentioned: 0 Post(s)
Quoted: 171 Post(s)
Activity Longevity
3/20 12/20
Today Posts
0/11 sssss3679
Re: Marijuana Use in Adolescence May Cause Permanent Brain Abnormalities

Urgh Only if your fucked up ALREADY will bud fuck you up MORE

Reply With Quote
The Following User Says Thank You to Parannoyed For This Useful Post:
chefbob09

Powered by vBulletin Copyright 2000-2010 Jelsoft Enterprises Limited.

Search Engine Friendly URLs by vBSEO