Go Back  

Chase and Run: Cancer Mechanism Breakthrough 

Current Rating:

Join NowJoin Now
  #1  
Old 06-19-2013, 04:52 PM
kellyhound's Avatar
kellyhound
Offline:
✝Moderator from Hell✝
Poster Rank:9
e-mail
Join Date: Oct 2006
Contributions: 412
 
Mentioned: 82 Post(s)
Quoted: 1755 Post(s)
Activity Longevity
13/20 20/20
Today Posts
11/11 ssss61159
Chase and Run: Cancer Mechanism Breakthrough

Quote:

Scientists in Britain believe they have finally discovered how cancer spreads around the body.

In a major breakthrough which could save millions of lives, their study has identified a mechanism known as “chase and run” which sees diseased and healthy cells group together to migrate to other organs.

The discovery by researchers at University College London may lead to a revolutionary therapy that blocks the action and keeps tumours in one place.

Cancer claims more than 150,000 lives each year in the UK but study spokesman Prof Roberto Mayor said: “Most deaths are not due to the formation of the primary tumor.

"Instead people die from secondary tumours originating from the first malignant cells, which are able to travel and colonise vital organs of the body such as the lungs or the brain.”

He added: “This happens because the cells get healthy ones to follow them. Nobody knew how this happened, and now we believe we have uncovered it.

“If that is the case it will be relatively easy to develop drugs that interfere with this interaction.”

The study, published in Nature Cell Biology, used two types of embryonic cells to simulate the roles of cancerous and healthy cells.

The researchers are confident the process in which cancer cells attach to healthy ones in order to migrate around the body works in a similar way.

Your Source For Death Pictures and Death Video
canc.jpg  

__________________
Reply With Quote
The Following 3 Users Say Thank You to kellyhound For This Useful Post:
Faline, Kanda444, Megamel29
  #2  
Old 06-19-2013, 05:06 PM
Faline's Avatar
Faline
Offline:
♥ Moderator ♥
Poster Rank:2
Gore Goddess
Join Date: Jun 2009
Contributions: 226
 
Mentioned: 85 Post(s)
Quoted: 1894 Post(s)
Activity Longevity
0/20 15/20
Today Posts
0/11 ssss93392
Re: Chase and Run: Cancer Mechanism Breakthrough

Could be a life changing discovery

Reply With Quote
  #3  
Old 06-19-2013, 05:19 PM
kellyhound's Avatar
kellyhound
Offline:
✝Moderator from Hell✝
Poster Rank:9
e-mail
Join Date: Oct 2006
Contributions: 412
 
Mentioned: 82 Post(s)
Quoted: 1755 Post(s)
Activity Longevity
13/20 20/20
Today Posts
11/11 ssss61159
Re: Chase and Run: Cancer Mechanism Breakthrough

also :

Quote:
Researchers have discovered how one of the world’s oddest mammals developed resistance to cancer, and there is hope that their work could help fight the disease in humans.

Naked mole rats live underground, where environmental conditions are harsh but predators are few. They can live for more than 30 years, almost seven years longer than their close cousin the house mouse—which is particularly susceptible to cancer. They breathe slowly due to the limited supply of oxygen, survive on very little food, have poor sight, and are largely indifferent to pain.

Naked mole rats are also the only mammals that do not regulate their body temperature. Because they live in colonies where the queen rat does the job of producing progeny and only a few males father the litters, their sperms become lazy.

For cancer researchers, mice and naked mole rats fall on two extremes of the disease spectrum. Mice are used as animal models of disease because of their short lives and high incidence of cancer, which help researchers study the mechanism of cancer occurrence and test drugs that fight the disease.

Naked mole rats, on the other hand, have never developed cancer in the years that they have been studied. In labs, researchers often don’t wait for their animal models to develop cancer. Instead they induce cancer by blasting the animals with gamma radiation, transplanting tumors, or injecting cancer-causing agents. Do that to a naked mole rat, though, and nothing happens.

Now, Vera Gorbunova and Andrei Seluanov at the University of Rochester think they may have found one mechanism by which naked mole rats defend themselves against cancer. Their results, reported today in the journal Nature, make for a strange tale.

While studying cells taken from the armpits and lungs of naked mole rats, they found an unusually thick chemical surrounding the cells. This turned out to be hyaluronan, a substance that is present in all animals, where its main job is to hold cells together. Beyond providing mechanical strength, it is also involved in controlling when cells grow in number.

Cancer relies on the unregulated growth of cells, so hyaluronan was thought to be involved in the progression of malignant tumors. According to Gorbunova, aspects of hyaluronan may regulate cell growth as well as hyaluronan's amount and thickness. As a polymer, the greater the number of hyaluronan molecules in a single chain, the thicker it becomes.

When the molecular mass is high, cells are “told” to stop increasing in number. When the molecular mass is low, they are “asked” to proliferate. In the case of the naked mole rat, Gorbunova found that the molecular mass was unusually high, as much as five times that of mice or humans.

To understand whether this unusual hyaluroanan was responsible for cancer resistance in naked mole rats, Gorbunova increased the amount of enzyme that degrades the chemical, reducing its molecular weight. Soon after, she observed that the rat’s cells readily started growing in thick clusters like cancerous mouse cells do.

In a separate experiment, she also tested this hypothesis by reducing the amount of hyaluronan by knocking out the genes that encode for its production. Then, on injecting cancer-causing virus, instead of resisting, the naked mole rat’s cells became cancerous.

Gorbunova thinks that having thick hyaluronan might have helped increase the elasticity of the rat’s skin, allowing it to live in small tunnels underground. This trait might then have accidentally developed a new role of preventing cancer.

Rochelle Buffenstein, a physiologist at the University of Texas Health Science Center, has studied naked mole rats for years and was pleased to see that some light has been shed on this creature’s remarkable resistance to cancer. “As we learn more about these cancer-resistant mechanisms that are effective and can be directly pertinent to humans, we may find new cancer prevention strategies,” she said.

__________________
Reply With Quote
The Following User Says Thank You to kellyhound For This Useful Post:
Kanda444
  #4  
Old 06-19-2013, 05:50 PM
WindBag's Avatar
WindBag
Offline:
My Rank: STAFF SERGEANT
Poster Rank:590
Join Date: Apr 2009
 
Mentioned: 0 Post(s)
Quoted: 12 Post(s)
Activity Longevity
1/20 15/20
Today Posts
0/11 ssssss985
Re: Chase and Run: Cancer Mechanism Breakthrough

very good news. I lost my aunt 2 years ago, now my uncle has prostate cancer and has to undergo surgery. maybe to late for him but could help millions.

Reply With Quote
The Following User Says Thank You to WindBag For This Useful Post:
kellyhound
  #5  
Old 06-19-2013, 07:00 PM
Kanda444's Avatar
Kanda444
Offline:
You holdin....?
Poster Rank:11
Join Date: May 2010
Contributions: 23
 
Mentioned: 227 Post(s)
Quoted: 20103 Post(s)
Activity Longevity
16/20 13/20
Today Posts
1/11 ssss49337
Re: Chase and Run: Cancer Mechanism Breakthrough

outstanding news!

__________________
"High moral character is not a precondition for great moral accomplishments."
Reply With Quote

Powered by vBulletin Copyright 2000-2010 Jelsoft Enterprises Limited.

Search Engine Friendly URLs by vBSEO