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Old 03-18-2012, 06:44 PM
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Neurofibromatosis - Tumours

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Neurofibromatosis (commonly abbreviated NF; neurofibromatosis type 1 is also known as von Recklinghausen disease) is a genetically-inherited disorder in which the nerve tissue grows tumors (neurofibromas) that may be benign or may cause serious damage by compressing nerves and other tissues. The disorder affects all neural crest cells (Schwann cells, melanocytes and endoneurial fibroblasts). Cellular elements from these cell types proliferate excessively throughout the body, forming tumors; melanocytes also function abnormally in this disease, resulting in disordered skin pigmentation and caf au lait spots. The tumors may cause bumps under the skin, colored spots, skeletal problems, pressure on spinal nerve roots, and other neurological problems.
Neurofibromatosis is an autosomal dominant disorder, which means only one copy of the affected gene is needed for the disorder to develop. Therefore, if only one parent has neurofibromatosis, his or her children have a 50% chance of developing the condition as well. The severity in affected individuals can vary, this may be due to variable expressivity. Approximately half of cases are due to de novo mutations and no other affected family members are seen. It affects males and females equally.
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Old 03-18-2012, 07:04 PM
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Re: Neurofibromatosis - Tumours

poor people
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Old 03-18-2012, 07:29 PM
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Re: Neurofibromatosis - Tumours

Only one word describes this, OH HELL NO! Ok I guess it was like 3 words.
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Old 03-18-2012, 07:50 PM
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Re: Neurofibromatosis - Tumours

One of my uncles had it but not as severe. Not blood uncle, he married my aunt. When i was little, it of course was really odd for me seeing someone with these lumps on them so it would freak me out a bit He would joke along with me and my brother though and tried to explain the condition. Still when it came to us leaving and giving goodbye kisses and hugs, the feel of the lumps against my cheeks were a bit odd lol
Was a lovely man, he passed away a few years ago.
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Old 03-18-2012, 11:17 PM
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Re: Neurofibromatosis - Tumours

and just when you think you're having a bad day!!
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Old 03-18-2012, 11:47 PM
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Re: Neurofibromatosis - Tumours

Damn. I'm sure those people get some pretty nasty looks out in public
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Old 03-19-2012, 12:22 AM
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Re: Neurofibromatosis - Tumours

It would straight up fucking suck to be any one of these people.
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Old 03-19-2012, 08:12 AM
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Re: Neurofibromatosis - Tumours

Jesus what a horrible disease. Any disease is bad but many you can't see. These poor people have to carry that around with them for all to see.
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Old 03-19-2012, 10:43 AM
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Re: Neurofibromatosis - Tumours

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Old 04-04-2012, 04:10 PM
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Re: Neurofibromatosis - Tumours

My friend's son had NF2. He brain tumors and tumors in his throat as well as external tumors. He died last November aged 34. His father, who also had it died last month. Awful disease
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